Hasil pencarian

Validated determination of diacerein and its active metabolite, rhein, by stability indicating constant pattern method as a novel manipulation of zero order spectra

Differential diagnosis of mucopolysaccharidosis and oligosaccharidosis of a sample of Egyptian children

Aurones and furoaurones: Biological activities and synthesis

Aurones, (Z)-2-benzylidenebenzofuran-3(2H)-ones, have proved to be promising bioactive compounds with a broad spectrum of activities including anticancer, antioxidant, antiparasitic and antibacterial activities. Aurones exhibited strong antiproliferative properties against cancer cells by acting on variable targets through different modes of action. Furoaurones, (Z)-2-benzylidenefurano[3,2-f] benzofuran-3(2H)-ones, is a class of semi synthetic compounds derived from naturally furanochromones extracted from of Ammi visnaga (L.) fruits. So, this literature review includes different biological activities of aurones and furoaurones and different methods for their synthesis

Acute and chronic toxicity profiles of the methanol leaf extract of Acacia ataxacantha D.C (Leguminosae) in Wistar rats

Acacia ataxacantha various parts have been reportedly used as herbal remedy for treatment of pains, microbial infections, ulcers, respiratory infection, mineral and vitamins supplements and dysentery. This study was conducted to ascertain the toxicity profile of methanol extract of Acacia ataxacantha in laboratory animals. The acute and chronic toxicity study was conducted according to the method of Lorke (1983) and OECD guidelines (2008) respectively. The oral lethal median dose (LD50) of the extract was estimated to ≥5000 mg/kg. The extract significantly increases (p ≤ 0.05) the liver (alanine transaminase, aspartate transaminase, alkaline phosphatase) and kidney (creatinine, urea and sodium ion) parameters at the dose of 400 mg/kg body weight. Histological examination revealed moderate glomerular necrosis and lymphocytes hyperplasia on the kidney (50, 200 and 400 mg/kg), the liver showed hepatocellular necrosis with kupffer cells hyperplasia, while mild mucosa necrosis was observed on stomach tissues. The extract is safe on acute administration, however prolong use may produce harmful effect on the liver, kidney and stomach.

Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with hlorphenirmaine maleate

In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin

Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE)

Reproductive indices in malaria infested mice treated with antimalarials, Phyllanthus amarus combined with vitamins

Validated potentiometric method for the determination of sulfacetamide sodium; application to its pharmaceutical formulations and spiked rabbit aqueous humor

The high lymphadenopathy and subcutaneous edema are associated with development of foot ulcer in type 2 diabetes: A collagen implanted antibiotic therapy

Stability indicating methods for selective determination of Oxetacaine in the presence of its degradation products

QbD-based design and characterization of mucoadhesive microspheres of quetiapine fumarate with improved oral bioavailability and brain biodistribution potential

POM analyses, immunomodulatory, cytotoxic activities and polyphenolic constituents of Callistemon viridiflorus fruits

Formulation and evaluation of gastro retentive tablets of clarithromycin prepared by using novel polymer blend

Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment

Evaluation of the physician’s acceptance to clinical pharmacy interventions after antibiotic stewardship implementation in the ICU in a general hospital in Egyp

Sapium ellipticum (Hochst) Pax leaf extract: Antioxidant potential in CCl4-induced oxidative stress model

Radical scavenging potential, antiinflammatory and antiarthritic activity of isolated isomer Methyl-γ-Orsellinate and roccellatol from Roccella montagnei Bel

Quality risk management during pharmaceutical ‘good distribution practices’ – A plausible solution

Quinazolino-thiadiazoles as antimicrobial agents